Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens
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چکیده
منابع مشابه
Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens.
For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoi...
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Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu²⁺, was studied by means of a TBARS assay. The antioxidan...
متن کاملHuman ACAT Inhibitory Effects of Flavonoids from Sophora flavescens
Acyl-coenzyme A:cholesterol acyltransferase (ACAT, EC 2.3.1.26) is the primary cellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-coenzyme A. It has been identified that two isoenzymes, ACAT-1 and ACAT-2, have different cell locations, membrane orientations, and metabolic functions. Atherosclerotic lesions are associated with the accumulation of c...
متن کاملSelective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry.
Flavonoids from Sophora flavescens were selectively extracted by mechanochemical-promoted extraction technology (MPET) after using response surface methodology to determine the optimal extraction parameters. The highest yield of 35.17 mg/g was achieved by grinding the roots with Na₂CO₃ (15%) at 440 rpm/min for 17.0 min and water was used as the sole solvent with a ratio of solvent to solid mate...
متن کاملLocalization of Prenylated Flavonoids in Sophora flavescens var. angustifolia Plants
A histochemical analysis was carried out on the distribution of flavonoid derivatives in Sophora flavescens var. angustifolia plant. Prenylated flavonoids such as kushenol I, kurarinone, sophoraflavanone G and des-O-methylanhydroicaritin were mainly localized in the peri derm (cork layers, and cork layer-like tissues scattered in parenchymatous tissues of the root system). Pterocarpan derivati...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2008
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.31.2097